Meprin Metalloproteases Inactivate Interleukin 6
نویسندگان
چکیده
منابع مشابه
Interleukin-6 Cleavage by Meprin Metalloproteinases A and B 1 Meprin Metalloproteases Inactivate Interleukin-6*
Meprins have been implicated in the pathogenesis of several inflammatory diseases including inflammatory bowel disease, in which the cytokine interleukin-6 (IL-6) is a prominent effector molecule. Because IL-6 levels are markedly elevated in meprin α and α/β knockout mice in an experimental model of IBD, the interaction between meprins and IL-6 were studied. The results demonstrate that rodent ...
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Soluble Interleukin-6 receptor (sIL-6R) mediated trans-signaling is an important pro-inflammatory stimulus associated with pathological conditions, such as arthritis, neurodegeneration and inflammatory bowel disease. The sIL-6R is generated proteolytically from its membrane bound form and A Disintegrin And Metalloprotease (ADAM) 10 and 17 were shown to perform ectodomain shedding of the recepto...
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The metalloproteases meprin α and meprin β exhibit structural and functional features that are unique among all extracellular proteases. Although meprins were discovered more than 30 years ago, their precise substrates and physiological roles have been elusive. Both enzymes were originally found to be highly expressed in kidney and intestine, which focused research on these particular tissues a...
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Type I fibrillar collagen is the most abundant protein in the human body, crucial for the formation and strength of bones, skin, and tendon. Proteolytic enzymes are essential for initiation of the assembly of collagen fibrils by cleaving off the propeptides. We report that Mep1a(-/-) and Mep1b(-/-) mice revealed lower amounts of mature collagen I compared with WT mice and exhibited significantl...
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Meprin metalloproteases, composed of alpha and/or beta subunits, consist of membrane-bound and secreted forms that are abundantly expressed in proximal tubules of the kidney as well as secreted into the urinary tract. Previous studies indicated that meprin metalloproteases play a role in pathological conditions such as ischemic acute renal failure and urinary tract infection. The aim of this wo...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.546309